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Are there animal-free methods to test the potential harmful effects of chemical substances on our health? A consortium of research organizations and companies developed new methods in the past four years. And with success!
Therefore, we would like to invite you to the symposium ‘Next level non-animal testing’ on December 2, 2022 in Utrecht, with keynote from Professor Marcel Levi, President Executive Board of the Dutch Research Council (NWO). Discover what has been done, what we can offer and how we can continue this innovative research together with you. The interactive conference is open for all stakeholders, researchers, companies, regulatory agencies, policy makers and NGOs. Will you attend our event? You can also attend our event via livestream. Register here!
3R TOXFLOW & DARTpaths
Within the 3R TOXFLOW project, funded by EFRO, small organisms (nematodes, fish and cells) are standardized to be used to assess hazards of substances while reducing the need for mammalian toxicity studies. The new methodologies are time and cost effective and as such highly suitable to assess even complex substances. The 3R TOXFLOW testing strategy supports companies in rapid assessment of their products and makes an important contribution to the transition to animal-free research in and outside the Netherlands.
Within the DARTpaths project, funded by the UK’s national organization for the 3Rs (NC3Rs), an in silico platform has been developed that allows integration of chemical, in vitro and in vivo toxicity data, based on molecular mechanisms of action. This allows translation of 3R TOXFLOW data and mammalian testing data into one shared prediction model. Mechanisms of action can consequently be confirmed using the 3R TOXFLOW testing strategy.
Acceptance of animal-free and novel test strategies requires bridging of all different study data. The 3R TOXFLOW testing strategy and the DARTpaths tools are key in this approach!
Professor Marcel Levi